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The purpose of the study is to evaluate the immune responses of UK infants after one or two doses of pneumococcal conjugate vaccine or one or two doses of three different types of meningococcal conjugate vaccine given at either two and three or two and four months of age.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vaccine schedule 1 | Experimental | Menjugate vaccine at 2 and 3 months |
|
| Vaccine schedule 2 | Experimental | Menjugate vaccine at 2 and 4 months |
|
| vaccine schedule3 | Experimental | Neissvacc at 2 and 3 months |
|
| vaccine schedule 4 | Experimental | Neissvacc at 2 and 4 months |
|
| Vaccine schedule 5 | Experimental | Meningitec at 2 and 3 months |
|
| Vaccine schedule 6 | Experimental | Meningitec at 2 and 4 months |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| menjugate | Biological | men C conjugate vaccine |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Immunogenicity | SBA men C responses | 3 months after last sample |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elizabeth Coates, PhD | Public Health England | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hertfordshire Primary Care Trusts | Welwyn Garden City | Hertfordshire | AL8 6JL | United Kingdom | ||
| Gloucestershire Primary Care Trusts |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16567982 | Result | Goldblatt D, Southern J, Ashton L, Richmond P, Burbidge P, Tasevska J, Crowley-Luke A, Andrews N, Morris R, Borrow R, Cartwright K, Miller E. Immunogenicity and boosting after a reduced number of doses of a pneumococcal conjugate vaccine in infants and toddlers. Pediatr Infect Dis J. 2006 Apr;25(4):312-9. doi: 10.1097/01.inf.0000207483.60267.e7. | |
| 20010312 |
| Label | URL |
|---|---|
| Published study results | View source |
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| Men C conjugate vaccine |
| Biological |
men C conjugate vaccine |
|
| Men C conjugate | Biological | men C conjugate vaccine |
|
| Men C Conjugate | Biological | men C conjugate vaccine |
|
| Men C conjugate | Biological | men C conjugate vaccine |
|
| Men C conjugate | Biological | men C conjugate vaccine |
|
| Gloucester |
| GL1 3NN |
| United Kingdom |
| Goldblatt D, Southern J, Ashton L, Andrews N, Woodgate S, Burbidge P, Waight P, Miller E. Immunogenicity of a reduced schedule of pneumococcal conjugate vaccine in healthy infants and correlates of protection for serotype 6B in the United Kingdom. Pediatr Infect Dis J. 2010 May;29(5):401-5. doi: 10.1097/INF.0b013e3181c67f04. |
| ID | Term |
|---|---|
| D011008 | Pneumococcal Infections |
| D008589 | Meningococcal Infections |
| ID | Term |
|---|---|
| D013290 | Streptococcal Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D016870 | Neisseriaceae Infections |
| D016905 | Gram-Negative Bacterial Infections |
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