Study Comparing a Pantoprazole Formulation to the Currently Marketed Tablet for GERD and Erosive Esophagitis

A Randomized, 2-Period, Crossover, Pharmacodynamic Comparability Study Comparing A Pantoprazole Spheroid Formulation to the Currently Marketed Tablet Formulation in Subjects With GERD and a History of Erosive Esophagitis.

The purpose of this study is to demonstrate pharmacodynamic comparability between the pantoprazole spheroid formulation and the marketed tablet formulation.

Inclusion Criteria:

• GERD and a history of Erosive Esophagitis documented by endoscopy
• H. pylori negative

Exclusion Criteria:

• Gastrointestinal conditions such as esophageal stricture, esophageal varices, previous vagotomy
• Achlorhydria