Factor V Leiden Mutation and Implantation Failure

Evaluation of the Role of Factor V Leiden Mutation in Implantation Failure

The purpose of this study is to determine whether inherited thrombophilias (tendency toward blood clotting) increase the risk of failure of the embryo to implant in IVF. The specific condition to be studied is the presence or absence of the Leiden mutation of the Factor V gene.

Inclusion Criteria:

• Women undergoing in-vitro fertilization with successful ovarian hyperstimulation, oocyte retrieval, and fertilization
• Transfer of at least 2 fresh embryos of Grade 2 (preembryo with blastomeres of equal size and <=10% cytoplasmic fragmentation) or better

Exclusion Criteria:

• Infertility due to uterine anatomic defect
• Current use of anticoagulant medication, such as heparin or aspirin
• Known presence of any other condition associated with increased risk of thrombosis