The purpose of this study is to determine if maternal infection with human papillomavirus (HPV) is associated with pregnancy complications including spontaneous preterm delivery (sPTD), severe preeclampsia (PE), and poor fetal growth.

Inclusion Criteria:

• All women presenting for prenatal care at the Hospital of the University of Pennsylvania or affiliated clinics

Exclusion Criteria:

• Multiple gestations
• Medical conditions such as diabetes, chronic hypertension, renal disease
• Fetal malformations or chromosomal anomalies
• Fetal death