The purpose of this study is to evaluate the feasibility and toxicity of the combination of paclitaxel, carboplatin, and topotecan in patients with previously untreated, stage III or IV epithelial ovarian carcinoma or primary peritoneal carcinoma. We will also make a preliminary evaluation of the efficacy of this three drug regimen in the initial treatment of these patients.

Upon determination of eligibility, all patients will be receive:

Paclitaxel + Carboplatin + Topotecan

a maximum of six courses of chemotherapy will be given at 21 day intervals

Inclusion Criteria:

To be included in this study, you must meet the following criteria:

• Epithelial ovarian carcinoma or primary peritoneal carcinoma
• Willing to consider second-look surgery to evaluate response if necessary
• No previous treatment with chemotherapy or radiation therapy
• Ability to perform activities of daily living with minimal assistance
• Adequate bone marrow, liver and kidney function
• Written informed consent

Exclusion Criteria:

You cannot participate in this study if any of the following apply to you:

• Age < 18 years
• Brain metastases
• Recent history of significant heart disease within 6 months
• Other significant medical conditions

Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.