Gemcitabine With Curcumin for Pancreatic Cancer

Phase II Trial of Gemcitabine and Curcumin in Patients With Advanced Pancreatic Cancer

The study hypotheasis is that curcumin, a natural compound with a potent antiproliferative effect, can improve the efficacy of the standard chemotherapy gemcitabine in patients with advanced pancreatic cancer. That is why the patients are given a daily oral dose of 8 gr of curcumin along the chemotherapeutic protocol of weekly gemcitabine.

Inclusion Criteria:

• locally advanced or metastatic adenocarcinoma of the pancreas
• no prior chemotherapy
• performance status 0-2
• adequate hematology and chemistry

Exclusion Criteria:

• serious concurrent medical condition