Biomechanical Effects of Duloxetine on Bladder and Sphincter Muscle Function in Women in Pure Genuine Stress Incontinence

Biomechanical Effects of Duloxetine on Bladder Function and Sphincter Resistance During the Emptying Phase and on Urethral Function During the Filling Phase of the Micturition Cycle in Women With Pure Genuine Stress Incontinence

Double-blind placebo-controlled study of the biomechanical effects of duloxetine compared with placebo in the treatment of women with pure genuine stress incontinence

Inclusion Criteria:

• Female
• Between 18 and 75 years of age
• Diagnosis of GSI
• Have discrete episodes of incontinence

Exclusion Criteria:

• Positive urine culture at visit 1
• Use of MAOI
• Have had continence or urethral surgery
• Use of anti-incontinence device, vaginal pessaries or medications for the treatment of urinary incontinence
• Began pelvic floor muscle exercises within 6 months prior to study entry.