IMRT Lower Limb Soft Tissue Sarcoma

A Phase II Study of Preoperative Intensity-Modulated Radiation Therapy For Lower Limb Soft Tissue Sarcoma

Intensity-modulated radiation therapy may make wound healing problems less likely by 1)precisely shaping the region of high radiation dose to the shape of the tissue which harbours tumour cells, and 2) precisely shaping the regions of low radiation dose to the shapes of the normal tissues which are more sensitive to radiation effects.

Inclusion Criteria:

• Histologically proven soft tissue sarcoma
• Lesion lies between the iliac crest (hipbone) and the ankle
• Lesion is newly diagnosed
• Assessed by radiation oncologist and surgical oncologist

Exclusion Criteria:

• Benign histologies
• Histologies generally treated with chemotherapy
• Prior or recurrent cancer, except nonmelanomatous skin cancer or carcinoma in-situ of the cervix