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Schizophrenia is a chronic, severe, and disabling brain disease. Auditory hallucinations are the most frequent symptoms with an incident of 50% to 70% in patients.
Transcranial Magnetic Stimulation (TMS) can significantly reduce symptoms of schizophrenia. TMS is capable of inducing changes in the electrical activities of the brain in humans.
The purpose of this trial is to study the use of TMS to decrease auditory hallucinations in schizophrenia.
We hypothesize that: True treatment with rTMS will have significant decrease in auditory hallucinations versus sham treatment over the temporoparietal cortex.
FMRI will highlight areas of activation with auditory hallucinations distinct from the area identified by Hoffman's scalp based method.
Cortical inhibition as measured by paired pulse TMS will be increased after true TMS but not sham TMS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| True Transcranial Magnetic Stimulation | Active Comparator | True treatment with TMS over the temporoparietal cortex. |
|
| Sham Transcranial Magnetic Stimulation | Sham Comparator | Sham treatment with rTMS over the temporoparietal cortex. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Paired Pulse | Device | True treatment with rTMS over the temporoparietal cortex. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hoffman Auditory Hallucination Scale | A series of 7 questions to identify the intensity and severity of the hallucinations | weekly |
| Measure | Description | Time Frame |
|---|---|---|
| Positive and Negative Syndrome Scale for Schizophrenia (PANSS) | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rose Marie Mueller, RN | Contact | 905-522-1155 | 36629 | rmueller@stjoes.ca |
| Sandra Chalmers, RN | Contact | 905-522-1155 | 35442 | schalmer@stjoes.ca |
| Name | Affiliation | Role |
|---|---|---|
| Gary Hasey, MD | St. Joseph's Health Care London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Joseph's Healthcare, rTMS Laboratory, 100 West Fifth Street | Recruiting | Hamilton | Ontario | L8N 3K7 | Canada |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| Paired Pulse | Device | Sham treatment with rTMS over the temporoparietal cortex. |
|
|
| St. Joseph's Healthcare, rTMS Laboratory, 100 West Fifth Street | Recruiting | Hamilton | Ontario | L8N 3K7 | Canada |