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To compare once daily versus 8 hour dosing of gentamicin for the treatment of chorioamnionitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Once daily Gentamicin | Active Comparator |
| |
| Every eight hour Gentamicin | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gentamicin | Drug | Daily gentamicin (5 mg/kg intravenously, then placebo doses IV after 8 and 16 hours). Eight hour gentamicin (2 mg/kg intravenously, then 1.5 mg/kg IV after 8 and 16 hours). |
| Measure | Description | Time Frame |
|---|---|---|
| Afebrile at 24 hours and no endometritis | 24 hours after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Neonatal outcomes | Time of delivery to time of discharge |
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Inclusion Criteria:
- clinical diagnosis of chorioamnionitis
Exclusion Criteria:
- maternal renal disease, intrauterine fetal death, allergy to gentamicin
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| Name | Affiliation | Role |
|---|---|---|
| Yasser Yehia El-Sayed | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University School of Medicine | Stanford | California | 94305 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20093909 | Result | Lyell DJ, Pullen K, Fuh K, Zamah AM, Caughey AB, Benitz W, El-Sayed YY. Daily compared with 8-hour gentamicin for the treatment of intrapartum chorioamnionitis: a randomized controlled trial. Obstet Gynecol. 2010 Feb;115(2 Pt 1):344-349. doi: 10.1097/AOG.0b013e3181cb5c0e. |
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| ID | Term |
|---|---|
| D002821 | Chorioamnionitis |
| ID | Term |
|---|---|
| D005315 | Fetal Diseases |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D005839 | Gentamicins |
| ID | Term |
|---|---|
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 | Carbohydrates |
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| D005322 | Fetal Membranes, Premature Rupture |
| D007744 | Obstetric Labor Complications |
| D010922 | Placenta Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |