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| ID | Type | Description | Link |
|---|---|---|---|
| 95908 | Other Identifier | Stanford University Alternate IRB Approval Number | |
| BRNCNS0003 | Other Identifier | Stanford University |
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The purpose of this study is to determine whether [18F]FHBG is suitable for use as an imaging probe in cancer or rheumatoid arthritis patients enrolled in cell or gene therapy trials. In this phase 1 study we will assess the safety and biodistribution of [18F]FHBG in patients.
The success of cell and gene therapy depends on specific targeting of the therapeutic gene or cell that is administered to the patient. Our goal is to develop an imaging method to non-invasively monitor the location of the therapeutic gene or cell. Imaging should help in the design of better protocols and potentially reduce side-effects of cell and gene therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| [18F]FHBG arm | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [18F]FHBG | Radiation | < 7mCi and 2 ug, iv |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| The primary endpoint of the study for each patient is acquisition of PET/CT image. | Time of scan |
| Measure | Description | Time Frame |
|---|---|---|
| Collection of vital signs, EKG, blood chemistry and CBC data | day 1, 2 and 8. |
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Inclusion Criteria:
- Clinical diagnosis of brain tumor or rheumatoid arthritis
Exclusion Criteria:
- Below 18 years of age
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| Name | Affiliation | Role |
|---|---|---|
| Sanjiv Sam Gambhir M.D., Ph.D. | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California Los Angeles | Los Angeles | California | 90095 | United States | ||
| Stanford University School of Medicine |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11483684 | Background | Yaghoubi S, Barrio JR, Dahlbom M, Iyer M, Namavari M, Satyamurthy N, Goldman R, Herschman HR, Phelps ME, Gambhir SS. Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med. 2001 Aug;42(8):1225-34. |
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| Stanford |
| California |
| 94305 |
| United States |
| ID | Term |
|---|---|
| D001932 | Brain Neoplasms |
| D001172 | Arthritis, Rheumatoid |
| D016543 | Central Nervous System Neoplasms |
| D005910 | Glioma |
| ID | Term |
|---|---|
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
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| ID | Term |
|---|---|
| C113308 | 9-(4-fluoro-3-hydroxymethylbutyl)guanine |
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