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| ID | Type | Description | Link |
|---|---|---|---|
| ZONMW grant 907-00-056 |
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| Name | Class |
|---|---|
| ZonMw: The Netherlands Organisation for Health Research and Development | OTHER |
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Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endotoxin | Drug | |||
| Potassium channel blockers: TEA, Quinin, Tolbutamide | Drug | |||
| L-NMMA | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamics | 24 hrs after LPS administration | |
| Markers of Inflammation | 24 hrs after LPS administration | |
| Cytokines | 24 hrs after LPS administration | |
| Markers of Renal Injury | 24 hrs after LPS administration | |
| Inducible NO synthase expression | 24 hrs after LPS administration | |
| NO-metabolites | 24 hrs after LPS administration | |
| Mediators of Vascular reactivity | 24 hrs after LPS administration | |
| Sensitivity to norepinephrine | 24 hrs after LPS administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Peter Pickkers, MD, PhD | Radboud University Medical Center | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16864730 | Result | Pickkers P, Dorresteijn MJ, Bouw MP, van der Hoeven JG, Smits P. In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia. Circulation. 2006 Aug 1;114(5):414-21. doi: 10.1161/CIRCULATIONAHA.105.590232. Epub 2006 Jul 24. |
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| ID | Term |
|---|---|
| D019446 | Endotoxemia |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D016470 | Bacteremia |
| D018805 | Sepsis |
| D007239 | Infections |
| D014115 | Toxemia |
| D018746 |
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| ID | Term |
|---|---|
| D004731 | Endotoxins |
| D014044 | Tolbutamide |
| D019323 | omega-N-Methylarginine |
| ID | Term |
|---|---|
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |
| D000096926 | Benzenesulfonamides |
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| Systemic Inflammatory Response Syndrome |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013449 |
| Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013453 | Sulfonylurea Compounds |
| D014508 | Urea |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D001120 | Arginine |
| D024361 | Amino Acids, Basic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
| D000601 | Amino Acids, Essential |