High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood

Treatment Protocol for High-Risk PNET Brain Tumors in Children With Surgery, Sequential Chemotherapy, Conventional and High-Dose With Peripheral Blood Stem Cell Transplantation and Radiation Therapy

The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.

Inclusion Criteria:

• Medulloblastoma in patients less than 5 years of age
• Brain PNET in patients less than 10 years of age
• Histologically documented diagnosis
• Body weight of > 8 kg

Exclusion Criteria:

• Parents' refusal