Tumor Hypoxia of Head-and-neck Cancer Underwent Radiation Therapy Measured With F-18-FMISO

Tumor Hypoxia of Head-and-neck Cancer Underwent Radiation Therapy Measured With F-18-FMISO

The purpose of this study is to describe the regional and global tumor hypoxia in head-and-neck cancer during percutaneous radiation therapy

Inclusion Criteria:

• histologically confirmed head-and-neck cancer not curable by surgery
• Karnofsky > 70%
• tumor volume and localisation allow curative radiotherapy
• written consent

Exclusion Criteria:

• metastases
• earlier radiation therapy of head and neck
• pregnancy
• secondary malignancy excluding dermal carcinoma and Tis-carcinoma of cervix uteri
• psychiatric impairment