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| ID | Type | Description | Link |
|---|---|---|---|
| GI 535/1-1 |
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| Name | Class |
|---|---|
| German Research Foundation | OTHER |
In both ageing and heart failure progressive exercise intolerance is observed. The Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study aims to investigate how aerobic short-term training interventions affect exercise capacity, left ventricular systolic and diastolic function, biomarkers of heart failure, skeletal muscle metabolism, and endothelial function in chronis heart failure patients (CHF-patients) and healthy subjects (HS) in two different age strata: Above 65 years and below 55 years.
Aim of the trial is therefore to compare the effects of aerobic exercise training in young and old healthy subjects as well as in young and old heart failure patients. To our knowledge this study is the first to prospectively investigate age differences of training responses in both CHF patients and age-matched healthy controls.
Because of the extensive clinical and molecular assessment the results of this trial will be made public in predefined substudies:
A total of 60 healthy subjects and 60 heart failure patients (in each group 30 <55 years, 30 >65 years) are prospectively randomized to either 4 weeks of aerobic ergometer training or control group.
Before and after the intervention period maximal exercise tolerance is determined by ergospirometry, endothelial function is measured by high-resolution A-mode ultrasound, left ventricular function by echocardiography including tissue Doppler imaging, and thigh muscle mass is assessed by CT. Skeletal muscle biopsies are obtained at both time-points and are analysed for inflammatory cytokines and markers of catabolism/anabolism.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic endurance exercise training (ergometer) | Behavioral |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in functional exercise capacity (as measured by cardiopulmonary exercise testing) | ||
| Echocardiography: Improvement in left ventricular diastolic function as assessed by tissue Doppler (E/E' ratio) |
| Measure | Description | Time Frame |
|---|---|---|
| Biomarkers of heart failure (including NT-proBNP) | ||
| Endothelial function | ||
| Activation of the catabolic ubiquitin-proteasome pathway |
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Inclusion Criteria:
Group 1: Healthy subjects
Group 2: CHF patients
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rainer P Hambrecht, MD | University of Leipzig, Heart Center, Dept. of Cardiology | Principal Investigator |
| Stephan Gielen, MD | University of Leipzig - Heart Center, Dept. of Internal Medicine/Cardiology | Principal Investigator |
| Volker Adams, PhD | University of Leipzig, Heart Center, Dept. of Internal Medicine/Cardiology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universität Leipzig, Herzzentrum, Klinik für Innere Medizin/Kardiologie | Leipzig | Saxony | 04289 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22565934 | Derived | Gielen S, Sandri M, Kozarez I, Kratzsch J, Teupser D, Thiery J, Erbs S, Mangner N, Lenk K, Hambrecht R, Schuler G, Adams V. Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation. 2012 Jun 5;125(22):2716-27. doi: 10.1161/CIRCULATIONAHA.111.047381. Epub 2012 May 7. | |
| 22267243 |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Derived |
| Sandri M, Kozarez I, Adams V, Mangner N, Hollriegel R, Erbs S, Linke A, Mobius-Winkler S, Thiery J, Kratzsch J, Teupser D, Mende M, Hambrecht R, Schuler G, Gielen S. Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. Eur Heart J. 2012 Jul;33(14):1758-68. doi: 10.1093/eurheartj/ehr469. Epub 2012 Jan 19. |