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To assess the effects of GTN on QT and QTc in subjects with And without atrial pacing. This will be done with and without autonomic blockade at two different pacing rates. Moxifloxacin effect on QT and QTc will also be assessed in atrially paced patients at two different pacing rates with and without autonomic blockade
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GTN | Drug | |||
| Moxifloxacin | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| QT and QTc changes at two different pacing rates in atrially paced patients |
| Measure | Description | Time Frame |
|---|---|---|
| Change in QT and QTcF before and after Moxifloxacin with and without autonomic blockade at each pacing rate Change in QT and QTcF before and after autonomic blockade at each pacing rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Bruxelles (Brussels) | Belgium | ||||
| Pfizer Investigational Site |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| Glasgow |
| Scotland |
| United Kingdom |
| Pfizer Investigational Site | Leicester | United Kingdom |
| Pfizer Investigational Site | Liverpool | United Kingdom |
| Pfizer Investigational Site | London | United Kingdom |
| Pfizer Investigational Site | Manchester | United Kingdom |
| ID | Term |
|---|---|
| D000077266 | Moxifloxacin |
| ID | Term |
|---|---|
| D024841 | Fluoroquinolones |
| D042462 | 4-Quinolones |
| D015363 | Quinolones |
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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