The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia.

The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia.

Investigate the role of tegaserod in modulating gastric sensitivity to mechanical distention of the stomach

Inclusion Criteria:

• Male or female subjects at least 18 years of age.
• Subjects willing to undergo multiple nasogastric intubations.
• Patients with functional heartburn will need to meet ROME II criteria.
• Patients with symptoms consistent with dyspepsia (epigastric pain/discomfort characterized by bloating, postprandial fullness and early satiety)

Exclusion Criteria:

• Subjects with clinically significant diarrhea or a diagnosis of diarrhea-predominant IBS.
• Subjects with a diagnosis of IBD, Barrett's esophagus, esophageal stricture or ring, or previous or current history of ulcer disease.
• Subjects with Diffuse Esophageal Spasm or Achalasia.

Other protocol-defined inclusion/exclusion criteria may apply.