Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With Hypertension

A Randomized, Double-blind, Parallel Group, Active-controlled, 38-week Study to Evaluate the Efficacy of Valsartan Versus Amlodipine on the Arterial Properties of Postmenopausal Women With Mild to Moderate Hypertension

The purpose of this study is compare treatment with valsartan with the possible addition of a diuretic, hydrochlorothiazide, on high blood pressure with the drug amlodipine with the possible addition of a diuretic, hydrochlorothiazide. In particular, the effect of treatment on the stiffness of the blood vessels will be studied.

Inclusion Criteria:

• Postmenopausal women
• Mild to moderate hypertension
• Statin therapy or LDL≤ 4.1 mmol/L

Exclusion Criteria:

• Severe hypertension
• LDL > 4.1 mmol/L if not taking anti-hyperlipidemic medication
• Certain hormonal therapy
• History of stroke, myocardial infarction, heart failure, chest pain, abnormal heart rhythm
• Liver, kidney, or pancreas disease
• Diabetes
• Raynaud's disease or any other significant peripheral vascular disease
• Allergy to certain medications used to treat high blood pressure

Other protocol-defined inclusion/exclusion criteria may apply.