Human Papilloma virus (HPV) are viruses that cause a common infection of the skin and genitals in men and women. Several types of HPV infection are transmitted by sexual activity and, in women, can infect the cervix (part of the uterus or womb). This infection often goes away by itself, but if it does not go away (this is called persistent infection), it can lead in women over a long period of time to cancer of the cervix. If a woman is not infected by HPV, it is very unlikely that she will get cervical cancer. This study will evaluate the consistency of consecutive vaccine lots and the non-inferiority of modified manufacturing processes of GSK Biologicals HPV-16/18 vaccine and the vaccine safety, over 12 months, in young adolescents and women of 10-25 years of age at study start. Approximately 750 study subjects will receive different lots of the HPV vaccine administered intramuscularly according to a 0-1-6 month schedule.

Inclusion Criteria:

• A woman between, and including, 10 and 25 years of age at the time of the first vaccination.
• Written informed consent from the subject prior to enrolment.
• Subject must be free of obvious health problems.
• Subject must have negative urine pregnancy test.

Exclusion Criteria:

• Pregnant or breastfeeding.
• Known acute or chronic, clinically significant pulmonary, cardiovascular, neurologic, hepatic or renal functional abnormality.
• History of chronic condition(s) requiring treatment such as cancer, chronic hepatitis or kidney disease(s), diabetes, or autoimmune disease.
• Previous vaccination against human papillomavirus (HPV).

Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.