Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP patientsChinese?

Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pain in Chinese? Part 2: Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP Patients

The effect of baclofen (GABAB agonist), diltiazem (muscle relaxant) and placebo will be compared in a double-blinded randomized study for the treatment of NCCP. Cerebral cortical, brainstem and spinal evoked potentials before and after treatment will be evaluated. Results of this study will shed lights on pathogenesis and treatment of NCCP in Chinese.We hypothesize that Baclofen alleviates visceral hyperalgesia in NCCP patients by suppressing afferent sensory pathway.

Inclusion Criteria:

• Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy
• Age between 18-70
• Gastroesophageal reflux disease
• Psychiatric illness
• Cerebrovascular accident
• Active peptic ulceration
• Heart failure or cardiac bradyarrhythmia
• Epilepsy
• Pregnancy or lactating female
• Previous hypersensitivity to muscle relaxant