Comparison of Pamidronate With Zoledronic Acid for Transplant Related Bone Loss Prevention

Comparison Between Pamidronate and Zoledronic Acid for the Treatment of Heart and Lung Transplant Related Osteopaenia and Osteoporosis

The purpose of this trial is to see whether zoledronic acid is better than pamidronate to treat low bone density in heart and lung transplant patients.

Inclusion Criteria:

• reduced bone density as indicated by a bone density T score <-1.in either the lumbar spine or femoral neck
• have undergone or are on the waiting list for heart or lung transplantation
• are receiving adequate calcium and vitamin D therapy
• have provided written informed consent prior to participation in the trial

Exclusion Criteria:

• untreated hypogonadism, hypothyroidism or hyperthyroidism
• acute or major organ rejection or intercurrent illness
• pregnancy or breastfeeding