A Phase I Study to Assess the Electrophysiologic Effects of BMS-394136 on the Atrium and Ventricle in Patients With Dual-Chamber Pacemakers or Defibrillators

Double-Blind, Randomized, Single-Dose Study to Evaluate the Atrial Selectivity and Safety of BMS-394136 in Patients With Implanted Dual-Chamber Pacemakers or Defibrillators

Double-Blind, Randomized, Single-Dose Study to Evaluate the Atrial Selectivity and Safety of BMS-394136 in Subjects with Implanted Dual-Chamber Pacemakers or Defibrillators

Inclusion Criteria:

• Patients with dual-chamber pacemakers or defibrillators

Exclusion Criteria:

• Recent acute ischemic events
• Recent atrial or ventricular arrhythmias
• Uncompensated heart failure
• Amiodarone use within last year
• Women of childbearing potential
• QTc <430 msec males
• QTc <450 msec females