Metabolic Capacity of Israeli Populations

Phenotypic and Genotypic Evaluation of Cytochrome P450 Isoforms in Populations of Different Ethnic Composition

The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions.

The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.

Inclusion Criteria:

• Age range 20-50
• Absence of significant disease state

Exclusion Criteria:

• The presence of significant disease states
• The regular use of drugs (including birth control pills)