A Phase IIA Study of BMS-512148 to Assess Safety, Exposure, and Biological Effects in Stable Type 2 Diabetic Subjects

A Double-blind, Placebo-controlled, Randomized, Multiple-dose Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Bms-512148 in Diabetic Subjects

The purpose of this clinical research study is to assess the safety of, exposure to, and biological effects of BMS-512148 in stable Type 2 diabetic subjects

Inclusion Criteria:

• Established diagnosis of Type 2 diabetes mellitus, who are treated with metformin or diet alone (drug naive).
• Fasting glucose (FG) < - 240 mg/dL, while on metformin or antidiabetic diet alone.
• HbA1c (Hemoglobin A1c) in the range of 6.0-10.0%

Exclusion Criteria:

• Women of childbearing potential