Multiple Ascending Dose Study of BMS-582949 in Patients With Stable Rheumatoid Arthritis on the Methotrexate Background

Multiple Ascending Dose Study of BMS-582949 in Patients With Stable Rheumatoid Arthritis on the Methotrexate Background

The purpose of this clinical research study is to learn if it is safe for rheumatoid arthritis patients to take BMS-582949 along with methotrexate.

Inclusion Criteria:

• Age 18-70 years
• Diagnosis of RA for ≥6 months
• Swollen or tender joint or ESR >ULN. Subject must be on stable doses of MTX
• Women of Childbearing Potential

Exclusion Criteria:

• Serum transaminase levels >ULN
• CK>ULN
• Cannot have taken Orencia or Remicade within 8 weeks of baseline, Humira or Enbrel within 4 weeks of baseline
• Use of H2 blockers or Proton Pump inhibitors while on study