Time to progression (physical examination and radiologic imaging

Inclusion Criteria:

• patients with primary ovarian cancer
• ECOG- 0-2
• Age >= 18
• no chemotherapy, radiation or immunotherapy in medical history for ovarian cancer
• adequate bone marrow, liver and kidney reserve: leukocytes ≥ 2.0 x 109/l, platelets ≥ 100 x 109/l, bilirubin <= 2,0 mg%, creatinine <= 1,5 mg% or creatinine clearance ≥ 60 ml/ min, hemoglobin ≥ 9 g/ dl SGOT, SGPT an AP within 3 fold of the reference laboratory's normal range
• written informed consent

Exclusion Criteria:

• before-existing heart illness, Cardiac infarct within last 6 months
• Radiotherapy within 4 weeks for study entry
• Patients in pregnancy or breast feeding (in premenopausal women anticonception has to be assured: intrauterine devices, surgical methods of sterilization, or, in hormone insensitive tumors only, oral, subcutaneous or transvaginal hormonal, non-estrogen containing contraceptives)