Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis

Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis: A Prospective Cross Over Trial

This study aims to evaluate the impact of nasal continuous positive airway pressure (nCPAP) treatment on liver enzymes in patients with sleep apnea syndrome and nonalcoholic steatohepatitis. Using a cross over design, the evolution of liver enzymes will be evaluated in 40 patients during a consecutive period of 6 weeks, with and without nCPAP treatment.

Inclusion Criteria:

• 18 to 70 years old
• Nonalcoholic steatohepatitis proven by liver biopsy
• Sleep apnea syndrome proven by polysomnography with an apnea-hypopnea index > 10 events/hour
• Informed consent

Exclusion Criteria:

• Psychiatric disorder
• Other cause of liver disease
• Professional driver