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The objective of this study is to assess the effectiveness of an atorvastatin treatment regimen involving starting doses between 10 and 80 mg, followed by a single-step titration (except for subjects started at 80mg), if required
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| atorvastatin | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion (%) of subjects achieving their LDL-C target after 12 weeks of treatment according to their 10-year CHD risk category (based on the new canadian guidelines on the management and treatment of dyslipidemia). |
| Measure | Description | Time Frame |
|---|---|---|
| The global proportion (%) of patients reaching targets when risk categories are combined The proportion (%) of subjects achieving BOTH their LDL-C and TC/HDL-C ratio targets after 6 and 12 weeks of treatment, globally and according to their 10-year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Calgary | Alberta | T2E 7C5 | Canada | ||
| Pfizer Investigational Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20151053 | Derived | Ur E, Langer A, Rabkin SW, Calciu CD, Leiter LA; CanACTFAST Study Investigators. Achieving cholesterol targets by individualizing starting doses of statin according to baseline low-density lipoprotein cholesterol and coronary artery disease risk category: the CANadians Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration (CanACTFAST) study. Can J Cardiol. 2010 Feb;26(2):80-6. doi: 10.1016/s0828-282x(10)70003-9. |
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| Calgary |
| Alberta |
| T3E 0C5 |
| Canada |
| Pfizer Investigational Site | Calgary | Alberta | T3G 3J9 | Canada |
| Pfizer Investigational Site | Edmonton | Alberta | T5A 4L8 | Canada |
| Pfizer Investigational Site | Edmonton | Alberta | T5K 2A2 | Canada |
| Pfizer Investigational Site | Edmonton | Alberta | T5N 2N8 | Canada |
| Pfizer Investigational Site | Coquitlam | British Columbia | V3K 3P4 | Canada |
| Pfizer Investigational Site | Coquitlam | British Columbia | V3K 3V9 | Canada |
| Pfizer Investigational Site | Kelowna | British Columbia | V1Y 2H4 | Canada |
| Pfizer Investigational Site | Langley | British Columbia | V3A 4H9 | Canada |
| Pfizer Investigational Site | Surrey | British Columbia | V3R 3P1 | Canada |
| Pfizer Investigational Site | Vancouver | British Columbia | V5Z 3J5 | Canada |
| Pfizer Investigational Site | Victoria | British Columbia | V8T 3P2 | Canada |
| Pfizer Investigational Site | Winnipeg | Manitoba | R2V 3P4 | Canada |
| Pfizer Investigational Site | Winnipeg | Manitoba | R3A 1R9 | Canada |
| Pfizer Investigational Site | Moncton | New Brunswick | E1G 1A7 | Canada |
| Pfizer Investigational Site | Rothesay | New Brunswick | E2E 2R2 | Canada |
| Pfizer Investigational Site | Saint John | New Brunswick | E2K 2T8 | Canada |
| Pfizer Investigational Site | Halifax | Nova Scotia | B3H 1V7 | Canada |
| Pfizer Investigational Site | Halifax | Nova Scotia | B3H 1Y6 | Canada |
| Pfizer Investigational Site | Halifax | Nova Scotia | B3K 5R3 | Canada |
| Pfizer Investigational Site | Halifax, B3K 5R3 | Nova Scotia | Canada |
| Pfizer Investigational Site | Brampton | Ontario | L6T 3J1 | Canada |
| Pfizer Investigational Site | Burlington | Ontario | L7M 4Y1 | Canada |
| Pfizer Investigational Site | Courtice | Ontario | L1E 3C3 | Canada |
| Pfizer Investigational Site | Downsview | Ontario | M3M 3E5 | Canada |
| Pfizer Investigational Site | Fort Erie | Ontario | L2A1Z3 | Canada |
| Pfizer Investigational Site | Hamilton | Ontario | L8M 1K7 | Canada |
| Pfizer Investigational Site | Hawkesbury | Ontario | K6A 1A1 | Canada |
| Pfizer Investigational Site | Kitchener | Ontario | N2C 2N9 | Canada |
| Pfizer Investigational Site | Lindsay | Ontario | K9V 6C5 | Canada |
| Pfizer Investigational Site | Markham | Ontario | L6B 1A1 | Canada |
| Pfizer Investigational Site | Midland | Ontario | L4R 4P4 | Canada |
| Pfizer Investigational Site | Napanee | Ontario | K7R 2G3 | Canada |
| Pfizer Investigational Site | Newmarket | Ontario | L3Y 5G8 | Canada |
| Pfizer Investigational Site | Niagara Falls | Ontario | L2E 7H1 | Canada |
| Pfizer Investigational Site | North Bay | Ontario | P1B 2H3 | Canada |
| Pfizer Investigational Site | North York | Ontario | M3J 1N2 | Canada |
| Pfizer Investigational Site | Oshawa | Ontario | L1H 1B9 | Canada |
| Pfizer Investigational Site | Oshawa | Ontario | L1J 2K9 | Canada |
| Pfizer Investigational Site | Ottawa | Ontario | K1C 1S6 | Canada |
| Pfizer Investigational Site | Saint Catherines | Ontario | L2N 7H8 | Canada |
| Pfizer Investigational Site | Saint Catherines | Ontario | L2S 3V7 | Canada |
| Pfizer Investigational Site | Sarnia | Ontario | N7T 4X3 | Canada |
| Pfizer Investigational Site | Thornhill | Ontario | L3T 4X1 | Canada |
| Pfizer Investigational Site | Thunder Bay | Ontario | P7E 4Z3 | Canada |
| Pfizer Investigational Site | Thunder Bay | Ontario | P7E 6E7 | Canada |
| Pfizer Investigational Site | Toronto | Ontario | M5C 2T2 | Canada |
| Pfizer Investigational Site | Toronto | Ontario | M5G 2C4 | Canada |
| Pfizer Investigational Site | Toronto | Ontario | M8V 3X8 | Canada |
| Pfizer Investigational Site | Toronto | Ontario | M9W 4L6 | Canada |
| Pfizer Investigational Site | Windsor | Ontario | N8X 1K4 | Canada |
| Pfizer Investigational Site | Charlottetown | Prince Edward Island | C1A 1L2 | Canada |
| Pfizer Investigational Site | Montague | Prince Edward Island | C0A 1R0 | Canada |
| Pfizer Investigational Site | Amos | Quebec | J9T 1T8 | Canada |
| Pfizer Investigational Site | Chicoutimi | Quebec | G7H 5H6 | Canada |
| Pfizer Investigational Site | Cowansville | Quebec | J2K 2X9 | Canada |
| Pfizer Investigational Site | Greenfield Park | Quebec | J4V 2G8 | Canada |
| Pfizer Investigational Site | Greenfield Park | Quebec | J4V 2H1 | Canada |
| Pfizer Investigational Site | Greenfield Park | Quebec | J4V2H1 | Canada |
| Pfizer Investigational Site | Laval | Quebec | H7N 2k2 | Canada |
| Pfizer Investigational Site | Laval | Quebec | H7T 2P5 | Canada |
| Pfizer Investigational Site | Laval | Quebec | H7V 2W3 | Canada |
| Pfizer Investigational Site | Le Gardeur | Quebec | J5Z 3C4 | Canada |
| Pfizer Investigational Site | Montreal | Quebec | H3A 1A1 | Canada |
| Pfizer Investigational Site | Montreal | Quebec | H3S 2W1 | Canada |
| Pfizer Investigational Site | Montreal | Quebec | H4N 2W2 | Canada |
| Pfizer Investigational Site | Montreal | Quebec | H4V 2R8 | Canada |
| Pfizer Investigational Site | Plessisville | Quebec | G6L 3J1 | Canada |
| Pfizer Investigational Site | Québec | Quebec | G1S 2L6 | Canada |
| Pfizer Investigational Site | Saint-Eustache | Quebec | J7P 2V1 | Canada |
| Pfizer Investigational Site | Saint-Léonard | Quebec | H1S 3A9 | Canada |
| Pfizer Investigational Site | Salaberry Du Valleyfield | Quebec | J6S 4Z5 | Canada |
| Pfizer Investigational Site | Sherbrooke | Quebec | J1H 4J6 | Canada |
| Pfizer Investigational Site | Ste. Foy | Quebec | G1V 4G2 | Canada |
| Pfizer Investigational Site | Vaudreuil | Quebec | J7V 8P9 | Canada |
| Pfizer Investigational Site | Regina | Saskatchewan | S4P 3X1 | Canada |
| Pfizer Investigational Site | Saskatoon | Saskatchewan | S7H 0W6 | Canada |
| Pfizer Investigational Site | Saskatoon | Saskatchewan | S7K 0H6 | Canada |
| Pfizer Investigational Site | Saskatoon | Saskatchewan | S7K 1N8 | Canada |
| Pfizer Investigational Site | Saskatoon | Saskatchewan | S7K 7H9 | Canada |
| Pfizer Investigational Site | Saskatoon | Saskatchewan | S7L 2W1 | Canada |
| Pfizer Investigational Site | St. John's | A1E 2C2 | Canada |
| Pfizer Investigational Site | St. John's | A1E 2E2 | Canada |
| ID | Term |
|---|---|
| D006937 | Hypercholesterolemia |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000069059 | Atorvastatin |
| ID | Term |
|---|---|
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006538 | Heptanoic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |
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