Omega-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Severe Chronic Heart Failure

Omega-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Severe Chronic Heart Failure:Effects On Endothelial Function, Left Ventricular Remodelling, Natriuretic Peptide Levels, And Exercise Capacity

To investigate whether n3-fatty acids have beneficial effects in chronic heart failure as regards circulatory function.

Inclusion Criteria:

• Chronic heart failure of non-ischemic origin
• Age ≥18 years
• NYHA functional class III-IV
• LVEF < 35 %
• Optimized heart failure therapy
• plasma NT-BNP >2000pg/ml

Exclusion Criteria:

• Current treatment with Omacor or other fish oil products
• Known hypersensitivity to the study drug
• Ischemic cardiomyopathy
• Uncorrected significant valvular heart disease
• Heart failure due to congenital heart disease
• Restrictive cardiomyopathy
• Alcoholic heart disease
• Acute myocarditis
• Continuous i.v. therapy for heart failure
• Mechanical assist device
• Life expectancy <1 year due to non-cardiac causes
• Inability to perform bicycle testing
• Women of childbearing potential not practicing a save contraception method
• Current participation in another intervention study
• Participation in another study with an intervention within the last 3 months.