Beta-CIT-SPECT and Neurophysiology in Depression

Serotonin and Dopamine Transporter (SERT, DAT) Availabilities as Assessed by b-CIT and SPECT, and Neurophysiological Measures of Central Serotonergic Activity in Patients With Depression Under Treatment With Escitalopram

Aim of this project is to investigate the effects of escitalopram on monoamine transporter (SERT, DAT) availabilities as assessed by b-CIT and SPECT, and on neurophysiological parameters such as the loudness dependence of auditory evoked potentials (LDAEP) in patients with depression.

Inclusion Criteria:

• Psychiatric in or outpatients with acute depressive episode
• Indication for pharmacological treatment

Exclusion Criteria:

• Acute suicidality
• Neurological or severe somatic disorders
• Occupational exposition to radiation >15 mSv per year
• Women during pregnancy or lactation