The Renin-Angiotensin System in Essential Hypertension | NCT00141583

Studies
The Renin-Angiotensin System in Essential Hypertension

NCT00141583

Sponsor

St George's, University of London

Status

Terminated

Last Update Posted

Jun 9, 2015Estimated

Enrollment

11Estimated

Phase

Not Applicable

Conditions

Hypertension

Interventions

Enalapril 20 mg bd
Candesartan 8 mg bd

Countries

United Kingdom

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

May 2007

Overall Recruitment Status or Expanded Access Status

Terminated

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Insufficient accrual rate

Expanded Access Info

Start Date

Apr 2004

Primary Completion Date

Not provided

Completion Date

Oct 2006Actual

First Submitted Date

Aug 31, 2005

First Submission Date that Met QC Criteria

Aug 31, 2005

First Posted Date

Sep 1, 2005Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jun 5, 2015

Last Update Posted Date

Jun 9, 2015Estimated

Description Module

Brief Summary

Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.

Detailed Description

Not provided

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

11Estimated

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Essential Hypertension
SBP 140-159 mmHg
DBP 90-99 mmHg

Exclusion Criteria:

Intolerance of or allergy to ACE Inhibitors or ARBS
Pregnant or Breastfeeding
Pre-menopausal women
Uncontrolled cardiac or renal failure
Diabetes mellitus

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

70 Years

Standard Ages

AdultOlder Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Name	Affiliation	Role
Timothy WR Doulton, BSc MRCP	SGUL	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Blood Pressure Unit, Dept. Cardiac & Vascular Sciences, SGUL		London		SW17 0RE	United Kingdom

Condition Browse Module

MeSH Terms

ID	Term
D006973	Hypertension

Ancestor Terms

ID	Term
D014652	Vascular Diseases
D002318	Cardiovascular Diseases

Browse Leaves

Not provided

Browse Branches

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D004656	Enalapril
C081643	candesartan

Ancestor Terms

ID	Term
D004151	Dipeptides
D009842	Oligopeptides
D010455	Peptides
D000602	Amino Acids, Peptides, and Proteins

Browse Leaves

Not provided

Browse Branches

Not provided

Measure	Description	Time Frame
Change in BP
Change in PRA and aldosterone

Name	Type	Description	Arm Group Labels	Other Names
Enalapril 20 mg bd	Drug
Candesartan 8 mg bd	Drug