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| ID | Type | Description | Link |
|---|---|---|---|
| ZonMw nr. 945-14-107 |
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| Name | Class |
|---|---|
| ZonMw: The Netherlands Organisation for Health Research and Development | OTHER |
The purpose of this study is to compare two different strategies to implement a new method to identify patients with HNPCC, which appeared cost-effective and feasible. The effectiveness, costs and feasibility of both of the implementation strategies will be assessed.
The Radboud University Nijmegen Medical Centre developed a new method to identify patients with HNPCC. This method appeared cost-effective and feasible. Using this new method 70% of the HNPCC patients will be identified as compared to less than 30% when the current method is used. However, this new method does not implement itself; large gaps exists between best evidence and daily practice. This study will compare an intensive strategy, consisting of distribution of educational materials, education, feedback and reminders, with a minimal strategy, only consisting of distribution of a critical care pathway. The aim is to find the most cost-effective strategy to implement the new method to identify patients with HNPCC in the Netherlands.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Education for professionals | Behavioral | |||
| Distribution of educational materials | Behavioral | |||
| Feedback for professionals | Behavioral | |||
| Reminders for professionals | Behavioral |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of inclusion of eligible CRC-patients for MSI testing by pathologists. | ||
| Efficacy of referral of patients who are MSI positive to a clinical geneticist by surgeons. |
| Measure | Description | Time Frame |
|---|---|---|
| Experiences with and acceptance of changed physician practice roles by patients and clinicians. | ||
| Cost efficacy of the implementation procedures. |
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Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lucy I Overbeek, MSc | Contact | +31-24-3613946 | l.overbeek@antrg.umcn.nl | |
| Nicoline Hoogerbrugge, MD PhD | Contact | +31-24-3613946 | n.hoogerbrugge@antrg.umcn.nl |
| Name | Affiliation | Role |
|---|---|---|
| Nicoline Hoogerbrugge, MD PhD | Department of Human Genetics, Radboud University Nijmegen Medical Center | Principal Investigator |
| Rosella P Hermens, MSc PhD | Center of Quality of Care Research, Radboud University Nijmegen Medical Center |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jeroen Bosch Ziekenhuis | Recruiting | 's-Hertogenbosch | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15591512 | Background | Kievit W, de Bruin JH, Adang EM, Severens JL, Kleibeuker JH, Sijmons RH, Ruers TJ, Nagengast FM, Vasen HF, van Krieken JH, Ligtenberg MJ, Hoogerbrugge N. Cost effectiveness of a new strategy to identify HNPCC patients. Gut. 2005 Jan;54(1):97-102. doi: 10.1136/gut.2004.039123. | |
| 16121665 | Background | de Bruin JH, Kievit W, Ligtenberg MJ, Nagengast FM, Adang EM, Ruers TJ, Kleibeuker JH, Sijmons RH, van Krieken JH, Hoogerbrugge N. [More hereditary intestinal cancer can be detected if patients with colorectal carcinoma that are selected by the pathologist are examined for microsatellite instability]. Ned Tijdschr Geneeskd. 2005 Aug 6;149(32):1792-8. Dutch. |
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| Meander Medisch Centrum | Recruiting | Amersfoort | Netherlands |
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| Ziekenhuis Rijnstate | Recruiting | Arnhem | Netherlands |
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| Pathologie laboratorium voor Dordrecht | Recruiting | Dordrecht | Netherlands |
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| Stichting laboratoria voor pathologische anatomie en medische microbiologie | Recruiting | Eindhoven | Netherlands |
|
| Laboratorium voor pathologie Oost-Nederland | Recruiting | Enschede | Netherlands |
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| Martini Ziekenhuis | Recruiting | Groningen | Netherlands |
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| Elkerliek Ziekenhuis | Recruiting | Helmond | Netherlands |
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| Laboratorium Volksgezondheid Friesland | Recruiting | Leeuwarden | Netherlands |
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| Canisius Wilhelmina Ziekenhuis | Recruiting | Nijmegen | Netherlands |
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| Medisch Centrum Rijnmond Zuid | Recruiting | Rotterdam | Netherlands |
|
| HagaZiekenhuis | Recruiting | The Hague | Netherlands |
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| St. Elisabeth Ziekenhuis | Recruiting | Tilburg | Netherlands |
|
| 20379742 | Derived | Overbeek LI, Hermens RP, van Krieken JH, Adang EM, Casparie M, Nagengast FM, Ligtenberg MJ, Hoogerbrugge N; MIPA study group. Electronic reminders for pathologists promote recognition of patients at risk for Lynch syndrome: cluster-randomised controlled trial. Virchows Arch. 2010 Jun;456(6):653-9. doi: 10.1007/s00428-010-0907-7. Epub 2010 Apr 9. |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D003123 | Colorectal Neoplasms, Hereditary Nonpolyposis |
| D053842 | Microsatellite Instability |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D009386 | Neoplastic Syndromes, Hereditary |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D049914 | DNA Repair-Deficiency Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D042822 | Genomic Instability |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D004522 | Educational Status |
| ID | Term |
|---|---|
| D012959 | Socioeconomic Factors |
| D011154 | Population Characteristics |
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