High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome

Pilot Study of Internal Globus Pallidus or Median Centre of the Thalamus High Frequency Stimulation for the Treatment of Patients With Severe Tourette's Syndrome

Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia. The aim of this study is to evaluate the effect of high frequency stimulation of the internal part of the globus pallidus and/or parafascicular-median centre of the thalamus, two structures implicated in the limbic circuit, in patients with severe Tourette's syndrome.

Inclusion Criteria:

• Tourette's syndrome (DSM IV)
• inducing a disability in the social and personal life
• No improvement with medical treatment
• Severe self suffering

Exclusion Criteria:

• Cognitive impairment (MMS < 24)
• Depression