The purpose of this study is to evaluate the immunogenicity, safety and reactogenicity of 3 doses of the meningococcal serogroup B vaccine when given, using either a 0-2-4 month or a 0-1-6 month schedule, to healthy adolescents aged 12-18 years; a control group will receive 2 doses of Havrix™ (0-6 months) and Meningitec™ (month 1).

The study is open; however, vaccines given to study group at 0-1-6 months and to control group will be administered in an observer-blind manner. 3 blood samplings for antibody testing: before vaccination and one month after the second and third vaccine doses.

Inclusion Criteria:

• Healthy males or females between, and including, 12 and 18 years of age at the time of the first vaccination.
• Female subjects must be of non-childbearing potential.

Exclusion Criteria:

• Previous vaccination against or history of meningococcal B or C, or hepatitis A disease or exposure to meningococcal B disease within last year.
• Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection.
• Family history of congenital or hereditary immunodeficiency.
• History of any neurologic disorders or seizures.

Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.