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The main aim of the study is to investigate whether taking Tolterodine for overactive bladder symptoms can reduce the thickness of the bladder wall, as measured by intra-vaginal ultrasound. This will help doctors to understand whether there is a link between changes in the thickness of the bladder wall and progression of symptoms.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tolterodine ER | Drug | |||
| Placebo | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| The main outcome will be the change in bladder wall thickness, as measured by intra-vaginal ultrasound from baseline to week 12. |
| Measure | Description | Time Frame |
|---|---|---|
| Secondary outcomes are the change in bladder wall thickness, as measured by intra-vaginal ultrasound from baseline to week 24 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Blackburn | Lancashire | BB2 3HH | United Kingdom | ||
| Pfizer Investigational Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37160401 | Derived | Stoniute A, Madhuvrata P, Still M, Barron-Millar E, Nabi G, Omar MI. Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults. Cochrane Database Syst Rev. 2023 May 9;5(5):CD003781. doi: 10.1002/14651858.CD003781.pub3. |
| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| Harrow |
| Middx |
| HA1 3UJ |
| United Kingdom |
| Pfizer Investigational Site | Oxford | Oxfordshire | OX3 9DU | United Kingdom |
| Pfizer Investigational Site | Livingston | West Lothian | EH54 6PP | United Kingdom |
| Pfizer Investigational Site | Basingstoke | RG24 9NA | United Kingdom |
| Pfizer Investigational Site | Birmingham | B15 2TG | United Kingdom |
| Pfizer Investigational Site | Cambs | PE18 8NT | United Kingdom |
| Pfizer Investigational Site | London | SE5 9RS | United Kingdom |
| Pfizer Investigational Site | London | W2 2YP | United Kingdom |
| Pfizer Investigational Site | Northampton | NN1 5BD | United Kingdom |
| Pfizer Investigational Site | Pl6 8Dh | United Kingdom |
| ID | Term |
|---|---|
| D014549 | Urinary Incontinence |
| ID | Term |
|---|---|
| D014555 | Urination Disorders |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D059411 | Lower Urinary Tract Symptoms |
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000068737 | Tolterodine Tartrate |
| ID | Term |
|---|---|
| D010665 | Phenylpropanolamine |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D001559 | Benzhydryl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D003408 | Cresols |
| D010636 | Phenols |
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