In a population of kidney transplant recipients having developed a first squamous cell carcinoma, the aim of the study is to assess the incidence of subsequent skin cancers over 2 years in patients who are switched to rapamycin as compared to patients who are maintained under calcineurin inhibitors.

Inclusion Criteria:

• First post-transplant squamous cell carcinoma in a kidney transplant recipient under calcineurin inhibitors

Exclusion Criteria:

• Other squamous cell carcinomas in the past history
• More than 2 transplantations
• Patients not under calcineurin inhibitors
• Unstable graft function
• Non controlled hyperlipidemia (cholesterol > 7.8 mmol/l or triglycerides > 3.95 mmol/l)
• Leucopenia < 3000/mm3
• Thrombocytopenia < 100,000/mm3
• Liver dysfunction
• Pregnancy
• Allergy to macrolides