Establishing a Tumor Bank in Families With Multiple Lymph... | NCT00131014

Studies
Establishing a Tumor Bank in Families With Multiple Lymphoproliferative Malignancies

NCT00131014

Sponsor

Dana-Farber Cancer Institute

Status

Recruiting

Last Update Posted

Apr 24, 2026Actual

Enrollment

1,500Estimated

Phase

Not provided

Conditions

Non-Hodgkin's Lymphoma
Hodgkin's Disease
Leukemia, Lymphocytic, Chronic
Lymphoproliferative Disorders

Interventions

Not provided

Countries

United States

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Apr 2026

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Aug 9, 2004Actual

Primary Completion Date

Jan 2033Estimated

Completion Date

Jan 2033Estimated

First Submitted Date

Aug 15, 2005

First Submission Date that Met QC Criteria

Aug 16, 2005

First Posted Date

Aug 17, 2005Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Apr 21, 2026

Last Update Posted Date

Apr 24, 2026Actual

Description Module

Brief Summary

The purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. The databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.

Detailed Description

Patients who participate will be asked to complete detailed family and medical history questionnaires initially, with a follow-up questionnaire every year.
Patients will be asked to supply a blood sample and possibly a mouthwash sample, both of which can be done by mail.
Patients will be asked to consent to the release of their lymphoma tissue block for the purposes of the study.
Patients will be given letters of invitation for their affected relatives to invite them to participate.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

Retention

Enrollment

1,500Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Next of Kin of deceased subj by lymphoma		Next of Kin of deceased subject by lymphoma
Subject unaffected by lymphoma		Subject unaffected by lymphoma
Subject affected by lymphoma		Subject affected by lymphoma

Interventions

Not provided

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Genetic factors that contribute to the development of lymphomas and CLL	Genetic factors that contribute to the development of lymphomas and CLL	Indefinite

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed.
Family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study.
Deceased family members may be included in the study. Public records such as death certificates may be used to confirm the history. Consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. The hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. Archived tissue samples may be used for genetic research.
Age > 18 years

Exclusion Criteria:

Subjects without a family history of lymphoma

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

Not provided

Standard Ages

AdultOlder Adult

Study Population

Group 1: Next of kin of a relative who has died from lymphoma Group 2: Subjects who have a next of kin diagnosed with lymphoma and/or CLL Group 3: Subjects who have had or have non-Hodgkin's lymphoma, CLL or Hodgkin's disease and had a relative who also had lymphoma or CLL

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Celeste Carey, MS	Contact	857-215-1646		celeste_carey@dfci.harvard.edu
Jennifer Brown, MD PhD	Contact	617-632-4564		Jennifer_Brown@dfci.harvard.edu

Overall Officials

Name	Affiliation	Role
Jennifer R. Brown, MD, PhD	Dana-Farber Cancer Institute	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Dana-Farber Cancer Institute	Recruiting	Boston	Massachusetts	02115	United States

Condition Browse Module

MeSH Terms

ID	Term
D008228	Lymphoma, Non-Hodgkin
D006689	Hodgkin Disease
D015451	Leukemia, Lymphocytic, Chronic, B-Cell
D008232	Lymphoproliferative Disorders

Ancestor Terms

ID	Term
D008223	Lymphoma
D009370	Neoplasms by Histologic Type
D009369	Neoplasms
D008206	Lymphatic Diseases

Browse Leaves

Not provided

Browse Branches

Not provided