Levosimendan Pretreatment for Weaning Patients From Cardio-Pulmonary Bypass

Impact of Levosimendan Pretreatment on Weaning From Cardiopulmonary Bypass (CPB) in Patients With Diminished Left Ventricular Function Before Coronary Artery Bypass Grafting (CABG)

The study evaluates the efficacy of intravenous levosimendan treatment started during a coronary artery bypass operation to wean patients from a heart lung machine.

Levosimendan or placebo infusion is started at the time of induction of anesthesia.

Inclusion Criteria:

• Three vessel coronary artery disease.
• Indication for on-pump coronary artery bypass surgery.
• Ejection fraction below 50%

Exclusion Criteria:

• Indication for any cardiac valve surgery
• Previous coronary artery bypass surgery