Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)

Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)

The purpose of this study is to determine if Atorvastatin can improve blood vessel stiffness and blood vessel function in children 10-18 years old with Type 1 and Type 2 diabetes. Subjects will receive atorvastatin 20mg or placebo daily for 3 months and will then switch therapies for the next 3 months.

Hypothesis: Atorvastatin will improve blood vessel function by decreasing arterial stiffness and improving blood flow.

Inclusion Criteria:

• Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM) for more than 1 year
• Age 10-18 years.

Exclusion Criteria:

• Cardiovascular disease (CVD)
• Liver disease
• Pregnancy
• Use of cholesterol or triglyceride lowering drugs
• Perceived inability to comply with the study protocol
• Endocrinopathy other than diabetes