A Study of Preoperative Radiation Therapy and Capecitabine in Locally Advanced Rectal Cancer

A Phase 2 Study of Preoperative Radiation Therapy and Capecitabine (an Oral Fluoropyrimidine Carbamate) in Locally Advanced Rectal Cancer

The purpose of this trial is to study the efficacy of preoperative radiation therapy and capecitabine in locally advanced rectal cancer.

The purpose of this trial is to study the efficacy of preoperative radiation therapy and capecitabine in locally advanced rectal cancer.

Inclusion Criteria:

• Biopsy - proven rectal cancer
• Transmural rectal wall invasion
• Karnofsky performance status >70
• Normal bone marrow, liver and kidney function

Exclusion Criteria:

• Distant metastases
• Prior pelvic radiation
• Inflammatory bowel disease
• Severe ischemic heart disease
• Anticoagulant therapy
• Pregnancy