Non-Nicotine Agents for Smoking Cessation

Non-Nicotine Agents for Smoking Cessation

The primary objective of this study is to determine which is the better approach to smoking cessation in veterans: bupropion combined with transdermal nicotine or high dose nicotine replacement therapy (NRT) using transdermal nicotine combined with nicotine inhaler.

This study is a two-arm open-label, randomized controlled trial of bupropion combined with transdermal nicotine versus high dose NRT (transdermal nicotine and nicotine inhaler) with all subjects receiving a behavioral counseling program for smoking cessation.

Inclusion Criteria:

• Readiness to set a quit date in the next two weeks,
• Current smoking of at least 15 cigarettes a day

Exclusion Criteria:

• Current untreated depression or receiving treatment for depression,
• History of seizures, major head injury, or other predisposition for seizures