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| ID | Type | Description | Link |
|---|---|---|---|
| 2005_021 |
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This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK0507A, dorzolamide hydrochloride (+) timolol maleate | Drug | |||
| Comparator: timolol maleate | Drug | |||
| Duration of Treatment: Part 1) 6 wk timolol maleate run in | Drug | |||
| Part 2) 6 wk washout pd Part 3) two 8 wk active tx pds | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| 24 hour diurnal IOP reduction after 8 weeks of treatment | After 8 weeks of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| IOP reduction a) from baseline at 6 weeks; b) comparison with timolol; c) comparison day versus night | At 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18627642 | Background | Feldman RM, Stewart RH, Stewart WC, Jia G, Smugar SS, Galet VA. 24-hour control of intraocular pressure with 2% dorzolamide/0.5% timolol fixed-combination ophthalmic solution in open-angle glaucoma. Curr Med Res Opin. 2008 Aug;24(8):2403-12. doi: 10.1185/03007990802243366. Epub 2008 Jul 14. | |
| 19441888 | Background |
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| Olander KW, Galet VA, Jia G, Smugar SS, Stewart WC. Relationship between visual field severity and response to fixed combination dorzolamide/timolol or timolol alone. J Ocul Pharmacol Ther. 2009 Aug;25(4):357-64. doi: 10.1089/jop.2008.0104. |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| C062765 | dorzolamide |
| D013999 | Timolol |
| ID | Term |
|---|---|
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D013830 | Thiadiazoles |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D009025 | Morpholines |
| D010078 | Oxazines |
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