This is a prospective, observational, longitudinal, multicenter study of patients with newly diagnosed follicular Non Hodgkin's Lymphoma (NHL) designed to delineate differences in clinical outcome by comparing the effectiveness and safety of common treatment regimens.

Inclusion Criteria:

• Signed Informed Consent Form (unless the Institutional Review Board [IRB] has granted a waiver of consent)
• Signed Authorization for the Use and Disclosure of Health Information document
• Age ≥18 years
• Histologic documentation of follicular NHL, according to Revised European-American Lymphoma (REAL) classification system, as assessed by the local pathologist and treating physician
• Initial diagnosis of follicular B-cell NHL within 6 months prior to enrollment
• Availability of cancer-specific historical data points in the patient's medical records

Exclusion Criteria:

• Other indolent or histologic NHL subtypes
• Diagnosis of lymphoma > 6 months prior to enrollment

Patients with follicular NHL will be recruited from participating managed care organizations, community physicians or practices, and academic centers throughout the United States.