The purpose of this study is to evaluate the safety, efficacy and exposure to TRM-1 in subjects with relapsed or refractory Non-Hodgkin's Lymphoma (NHL).

Primary Inclusion Criteria:

• Relapsed or refractory histologically confirmed Non-Hodgkin's Lymphoma
• Previously treated with at least 1 therapeutic regimen and relapsed or progressed or failed to achieve a response after the last regimen
• 18 years of age or older

Primary Exclusion Criteria:

• Received a non-FDA approved investigational agent within the last 4 weeks
• Received cancer therapies (chemotherapy, biological therapy [including hormonotherapy], radiation therapy or immunosuppressants within the last 3 weeks, 8 weeks for monoclonal antibodies, radioimmunotherapy or nitrosourea
• Eligible for a hematopoietic stem cell transplant (HSCT) or have had an autologous HSCT within the last 16 weeks
• Prior history of an allogeneic HSCT
• HIV, AIDS-related lymphoma, central nervous system (CNS) lymphoma, Hepatitis-B or Hepatitis-C
• Infection requiring antibiotics within the last 4 weeks
• Major surgery within the last 4 weeks
• Pregnant or breast-feeding women
• History of other cancers within the past 5 years