This is a placebo-controlled study evaluating the effectiveness of medication in elderly subjects with Major Depressive Disorder (MDD).

Inclusion Criteria:

• Primary diagnosis of Major Depressive Disorder with DSM-IV criteria for their current episode for at least 8 weeks.

Exclusion Criteria:

• Patient has current or past history of seizure disorder or brain injury.
• Patient has a diagnosis of anorexia or bulimia within the past 12 months.
• Patient has a past or current DMS-IV diagnosis of schizophrenia or any other psychotic disorder(s).
• Patient has had a myocardial infarction within 1 year or a history of uncontrolled hypertension or unstable heart disease with 6 months.