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| ID | Type | Description | Link |
|---|---|---|---|
| 2004_022 |
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The purpose of this study is to test the effectiveness of an approved drug in the early treatment of migraine while the pain is still mild.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK0462, rizatriptan benzoate / Duration of Treatment: 1day | Drug | |||
| Comparator: placebo / Duration of Treatment: 1 day | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients who are pain free at 2 hours postdose. | ||
| Tolerability as measured by subjective adverse experience reporting. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of patients with 24 hour sustained pain freedom | ||
| Percentage of patients free at 30/45/60/90 minutes postdose | ||
| Percentage of patients with associated symptoms at 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16732837 | Background | Cady R, Martin V, Mauskop A, Rodgers A, Hustad CM, Ramsey KE, Skobieranda F. Efficacy of Rizatriptan 10 mg administered early in a migraine attack. Headache. 2006 Jun;46(6):914-24. doi: 10.1111/j.1526-4610.2006.00466.x. | |
| 18005144 | Background | Martin V, Cady R, Mauskop A, Seidman LS, Rodgers A, Hustad CM, Ramsey KE, Skobieranda F. Efficacy of rizatriptan for menstrual migraine in an early intervention model: a prospective subgroup analysis of the rizatriptan TAME (Treat A Migraine Early) studies. Headache. 2008 Feb;48(2):226-35. doi: 10.1111/j.1526-4610.2007.00947.x. Epub 2007 Nov 13. |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| C093622 | rizatriptan |
| D000081206 | Duration of Therapy |
| ID | Term |
|---|---|
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
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| Percentage of patients requiring rescue med between 2 & 24 hours |
| Percentage of patients with functional disability at 2 hours |
| 17681023 | Background | Cady R, Martin V, Mauskop A, Rodgers A, Hustad C, Ramsey K, Skobieranda F. Symptoms of cutaneous sensitivity pre-treatment and post-treatment: results from the rizatriptan TAME studies. Cephalalgia. 2007 Sep;27(9):1055-60. doi: 10.1111/j.1468-2982.2007.01391.x. Epub 2007 Aug 6. |
| 19222588 | Background | Ho TW, Rodgers A, Bigal ME. Impact of recent prior opioid use on rizatriptan efficacy. A post hoc pooled analysis. Headache. 2009 Mar;49(3):395-403. doi: 10.1111/j.1526-4610.2009.01346.x. Epub 2008 Feb 12. |
| D009422 | Nervous System Diseases |