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| ID | Type | Description | Link |
|---|---|---|---|
| 2004_047 |
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The purpose of this study is to determine whether an investigational medication will be more effective than an approved medication in reducing cholesterol levels.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK0653, ezetimibe / Duration of Treatment: 28 weeks | Drug | |||
| Comparator: atorvastatin / Duration of Treatment: 28 weeks | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the effect on the reduction in low density lipoprotein cholesterol (LDL-C) after the initial 6-week treatment period. |
| Measure | Description | Time Frame |
|---|---|---|
| Assess safety/tolerability and evaluate effect on HDL-C & on reduction of LDL-C | ||
| Evaluate % of pts who attain their NCEP-ATP III goal for LDL-C @ each dose level |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15194018 | Background | Ballantyne CM, Blazing MA, King TR, Brady WE, Palmisano J. Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia. Am J Cardiol. 2004 Jun 15;93(12):1487-94. doi: 10.1016/j.amjcard.2004.02.060. | |
| 16369229 | Background | McKenney J, Ballantyne CM, Feldman TA, Brady WE, Shah A, Davies MJ, Palmisano J, Mitchel YB. LDL-C goal attainment with ezetimibe plus simvastatin coadministration vs atorvastatin or simvastatin monotherapy in patients at high risk of CHD. MedGenMed. 2005 Jul 14;7(3):3. |
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| 16004682 | Background | Catapano A, Brady WE, King TR, Palmisano J. Lipid altering-efficacy of ezetimibe co-administered with simvastatin compared with rosuvastatin: a meta-analysis of pooled data from 14 clinical trials. Curr Med Res Opin. 2005 Jul;21(7):1123-30. doi: 10.1185/030079905X50642. |
| ID | Term |
|---|---|
| D006937 | Hypercholesterolemia |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000069438 | Ezetimibe |
| D000081206 | Duration of Therapy |
| ID | Term |
|---|---|
| D001384 | Azetidines |
| D001385 | Azetines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
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