The purpose of this study is to test whether SU011248 has activity and is safe in patients with metastatic non-small cell lung cancer (NSCLC) who have failed a platinum-containing regimen and docetaxel.

Inclusion Criteria:

• Histologically confirmed advanced or metastatic Non-Small Cell Lung Cancer that cannot be cured with surgery, radiation, or combination thereof
• No more than 2 prior chemotherapy treatments including treatment with a platinum containing therapy
• Evidence of measurable disease by radiographic technique
• Male or Female, 18 years or older
• ECOG performance status of 0 or 1
• Resolution of all acute toxicities of prior therapies
• Adequate organ function

Exclusion Criteria:

• Major surgery or radiation therapy within 4 weeks
• Severe hemorrhage within 4 weeks
• Previous treatment with anti-angiogenesis agents
• Diagnosis of second malignancy within last five 5 years
• History of or known brain metastases, spinal cord compression, or carcinomatous meningitis
• Known HIV
• Serious acute or chronic illness
• Current treatment on another clinical trial
• Pregnant or breastfeeding