Study Evaluating DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive Disorder

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Flexible-Dose Study of DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive Disorder

To compare the antidepressant efficacy and safety of DVS-233 SR versus placebo in adult outpatients with MDD.

Inclusion Criteria:

• Outpatients.
• Sexually active individuals participating in the study must use a medically acceptable form of contraception during the study and for at least 15 days after the last dose of test article
• Subjects must have a primary diagnosis of major depressive disorder

Exclusion Criteria:

• Treatment with DVS-233 SR at any time in the past
• Treatment with venlafaxine (immediate release [IR] or ER) within 90 days of study day 1
• Known hypersensitivity to venlafaxine (IR or ER)