Key Adverse Events After Childhood Cancer
Key Adverse Events After Childhood Cancer
This clinical trial studies cancer survivors to identify those who are at increased risk of developing late-occurring complications after undergoing treatment for childhood cancer. A patient's genes may affect the risk of developing complications, such as congestive heart failure, avascular necrosis, stroke, and second cancer, years after undergoing cancer treatment. Genetic studies may help doctors identify survivors of childhood cancer who are more likely to develop late complications.
PRIMARY OBJECTIVES:
I. To identify key adverse events developing in patients (cases) with a primary cancer diagnosed at age 21 or younger.
II. To characterize the key adverse events with respect to the nature of the primary malignancy (pathology, stage) and coded details of the therapeutic protocol.
III. To identify treatment-related and demographic risk factors through a direct comparison of the case-group and controls identified from the remaining patients with the same primary diagnosis.
IV. To compare the frequency of mutations or polymorphisms in specific candidate genes in cases and controls, using constitutional deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) from the cases and controls.
V. To explore the role and nature of gene-environment interaction in the development of key adverse events.
OUTLINE:
DNA and RNA from peripheral blood or saliva sample of patients is analyzed for the presence of polymorphisms in genes associated with an increased risk of late-occurring complications.
Inclusion Criteria:
ELIGIBILITY CRITERIA - CASES
Diagnosis of primary cancer at age 21 or younger, irrespective of current age
No prior history of allogeneic (non-autologous) hematopoietic cell transplant
Development of one of the following key adverse events at any time following initiation of cancer therapy:
Submission of a blood specimen (or in certain cases a saliva specimen) to the Coordinating Center at the University of Alabama at Birmingham as per the requirements; please note: if a patient is currently receiving active cancer treatment, it is preferable to obtain the blood sample at a time when the patient's white blood cell (WBC) is > 2,000
Written informed consent from the patient and/or the patient's legally authorized guardian
In active follow up by a COG institution; active follow up will be defined as date of last visit or contact by a COG institution within the past 24 months; any type of contact, including contact specifically for participation in ALTE03N1, qualifies as active follow-up; please note: treatment on a COG (or legacy group) therapeutic protocol for the primary cancer is NOT required
ELIGIBILITY CRITERIA - CONTROLS
CONTROL: Diagnosis of primary cancer at age 21 or younger, irrespective of current age
CONTROLS: No prior history of allogeneic (non-autologous) hematopoietic cell transplant
CONTROLS: No clinical evidence of any of the following key adverse events:
CONTROLS: Submission of a blood specimen (or in certain cases a saliva specimen) to the Coordinating Center Laboratory at the University of Alabama at Birmingham as per the requirements
CONTROLS: Written informed consent from the patient and/or the patient's legally authorized guardian
CONTROLS: In active follow up by a COG institution; active follow up will be defined as date of last visit or contact by a COG institution within the past 24 months; any type of contact, including contact specifically for participation in ALTE03N1, qualifies as active follow-up; please note: treatment on a COG (or legacy group) therapeutic protocol for the primary cancer is NOT required
Miami, Florida 33136, United States
Minneapolis, Minnesota 55404, United States
New York, New York 10032, United States
Houston, Texas 77030, United States
Spokane, Washington 99204, United States